What is the Complement 3 Glomerulopathy Market?

 



What does mean by Complement 3 Glomerulopathy?

Complement 3 Glomerulopathy (C3G) is a rare kidney disease that has two forms: dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). Each is caused by genetic or acquired problems in controlling the body’s complement system, which helps fight infections. Genetic problems can be inherited or not inherited. The acquired complications arise during a person’s life. C3G can have a major impact on a person’s health. The signs and symptoms of DDD tend to appear earlier than those of C3GN (usually in adolescence). However, the signs and symptoms of either form of C3G may not begin until adulthood. People with C3G often have symptoms which are related to problems with the kidney and other parts of the body.

What is the Complement 3 Glomerulopathy Market?

DelveInsight's "Complement 3 Glomerulopathy Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Complement 3 Glomerulopathy, historical and forecasted epidemiology as well as the Complement 3 Glomerulopathy market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

What are the Complement 3 Glomerulopathy Emerging Drugs?

·         Avacopan: Novartis Pharmaceuticals

Avacopan is an orally-administered drug candidate that inhibits the complement C5a receptor, or C5aR, and is being developed for inflammatory and autoimmune diseases. Avacopan blocks the activity of complement C5a, a component of the complement system and the natural ligand for C5aR. It is in phase II stage of development to treat C3 Glomerulopathy

·         LNP 023: Novartis Pharmaceuticals

Iptacopan is an investigational, first-in-class, orally administered factor B inhibitor of the alternative complement pathway, targeting one of the key drivers of these diseases9-11. It has the potential to become the first targeted therapy to delay progression to dialysis in C3G. It is in phase II stage of development to treat C3 Glomerulopathy

What is the Complement 3 Glomerulopathy Market Size Report?

The Complement 3 Glomerulopathy market report provides current treatment practices, emerging drugs, Complement 3 Glomerulopathy market share of the individual therapies, current and forecasted Complement 3 Glomerulopathy market Size from 2019 to 2032 segmented by seven major markets. The Report also covers current Complement 3 Glomerulopathy treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the Complement 3 Glomerulopathy market.

What is the Complement 3 Glomerulopathy Market Outlook?

According to the National Kidney Foundation (NKF), C3G stands for complement 3 glomerulopathy. The “C3” refers to a blood protein that plays a key role in normal immunity and in the development of this disease whereas the “G” is for glomerulopathy, meaning damage to the glomeruli in the kidney. In addition, C3G includes dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), which represent the two different patterns of damage and inflammation in the glomeruli. In other words, the damage and inflammation in the kidney tissue in DDD look different from that in C3GN when seen under a microscope. Since there are no approved therapies for C3G, the market is mainly dominated by the use of off-label prescription drugs.

Treatments for C3G include Immunosuppressants in combination with corticosteroids, Renin–angiotensin–aldosterone system Inhibitors (RAAS), and other supportive therapies (calcineurin inhibitors, anticomplement therapies with eculizumab). However, the current emerging market of C3G possesses an intermediate pipeline. There are no emerging therapies in their phase III developmental stage; however, a few potential emerging players are investigating their product candidates in late- and mid-phase of developmental stage, namely, ChemoCentryx (Avacopan), Omeros Corporation (Narsoplimab), Apellis Pharmaceuticals (Pegcetacoplan), and Novartis Pharmaceuticals (Iptacopan (LNP023)). Other actively developing early stage players are Amyndas Pharma and Visterra.

The Complement 3 Glomerulopathy market outlook of the report helps to build a detailed comprehension of the historic, current, and forecasted Complement 3 Glomerulopathy market trends by analyzing the impact of current Complement 3 Glomerulopathy therapies on the market, unmet needs, drivers and barriers, and demand for better technology. This segment gives a thorough detail of Complement 3 Glomerulopathy market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated Complement 3 Glomerulopathy market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

Source: Complement 3 Glomerulopathy Market Companies

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